Evaluation of effect of epidermal growth factor receptor and vascular endothelial growth factor overexpression in survival of patients with glioblastoma multiforme

Background. In the central nervous system, glioblastoma multiforme (GBM) is one of most important neoplasms in adults. Amplification EGFR and VEGF genes common GBM. However, role overexpression survival patients with GBM has been a contentious issue. Therefore, we performed present study to assess rate overexpression. Materials methods. Resected samples were evaluated by immunohistochemistry for EGFR. The followed up year. Results. mean±sd age was 56.2±13.1 years. majority male (65.9%). Most had primary (67%), notwithstanding 33% secondary Moreover, 19.2% 49.5% VEGF-positive EGFR-positive, respectively. Overall 6, 12-, 18-month rates shown be 61.5±5.1%, 17.6±4%, 4.4±2.1%, There significant difference between mean±se VEGF-negative (12±1.9 months) (7.8±0.5 (P=0.045). Conclusions. We found an association over-expression patients. significantly associated overall patients, but failed have prognostic value their mortality rate. predictor overexertion stronger GBM, compared